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Open Access Research

Investigating the complexity of respiratory patterns during the laryngeal chemoreflex

Andrei Dragomir1, Yasemin Akay1, Aidan K Curran2 and Metin Akay1*

Author Affiliations

1 Harrington Department of Bioengineering, Ira A. Fulton School of Engineering Arizona State University, Tempe, AZ 85287, USA

2 Department of Physiology, Dartmouth Medical School, NH 03756, USA

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Journal of NeuroEngineering and Rehabilitation 2008, 5:17  doi:10.1186/1743-0003-5-17

Published: 20 June 2008

Abstract

Background

The laryngeal chemoreflex exists in infants as a primary sensory mechanism for defending the airway from the aspiration of liquids. Previous studies have hypothesized that prolonged apnea associated with this reflex may be life threatening and might be a cause of sudden infant death syndrome.

Methods

In this study we quantified the output of the respiratory neural network, the diaphragm EMG signal, during the laryngeal chemoreflex and eupnea in early postnatal (3–10 days) piglets. We tested the hypothesis that diaphragm EMG activity corresponding to reflex-related events involved in clearance (restorative) mechanisms such as cough and swallow exhibit lower complexity, suggesting that a synchronized homogeneous group of neurons in the central respiratory network are active during these events. Nonlinear dynamic analysis was performed using the approximate entropy to asses the complexity of respiratory patterns.

Results

Diaphragm EMG, genioglossal activity EMG, as well as other physiological signals (tracheal pressure, blood pressure and respiratory volume) were recorded from 5 unanesthetized chronically instrumented intact piglets. Approximate entropy values of the EMG during cough and swallow were found significantly (p < 0.05 and p < 0.01 respectively) lower than those of eupneic EMG.

Conclusion

Reduced complexity values of the respiratory neural network output corresponding to coughs and swallows suggest synchronous neural activity of a homogeneous group of neurons. The higher complexity values exhibited by eupneic respiratory activity are the result of a more random behaviour, which is the outcome of the integrated action of several groups of neurons involved in the respiratory neural network.